Structure of PDB 3pif Chain B Binding Site BS01

Receptor Information
>3pif Chain B (length=1056) Species: 28985 (Kluyveromyces lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IPKFFHFISERWPQISQLIDGSQIPEFDNLYLDMNSILHNCTHGRLSEEE
VYSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRARRFRTAMDAE
KALQKAFDSNAITPGTEFMAKLTENLKYFIHDKITNDTRWQNVKVIFSGH
EVPGEGQHKIMDYIRAIRAQEDYNPNTRHCIYGLDADLIILGLSTHDHHF
CLLREEVTTLETQNFFLLHLSILREYLALEFEEITDSVQFEYDFERVLDD
FIFVLFTIGNDFLPNLPDLHLKKGAFPVLLQTFKEALQHMDGYINEQGKI
NLARFSIWLKYLSDFEYLNFEKKDIDVEWFNQQLENISLEGERKRTRMGK
KLLMKQQKKLIGAVKPWLLKTVQRKVTSDADFEIFPLEDKELVRANLDFL
KEFAFDLGLILAHSKSKDLYYFKLDLDSIAAAAAAAAAAAAAAAAAAAYS
ERFVEWKDQYYKDKDTDSLKEMTENYVGGLQWVLYYYYRGCPSWSWYYRY
HYAPRISDVIKGIDQNIEFHKGQPFKPFQQLMAVLPERSKNLIPVVYFYP
NEVVVKISFVDQKRLVEAMAPYDAKLSPDEKKRNSFGTDLIFIFNPQVDT
VYKTPLAGLFNDIEHNHCIEREFIPESMENVKFLFGLPKGAKLGASSLAG
FPSLKTLPLTAELAYNSSVVFNFPSKQQSMVLHIQDLYSLSDLAKRHMGK
IVYSRWPFLRESKLLSLITEETVYEGVKSGKLTKVIERKPQDFERKEFRE
LKMTLKSNYQRTKAILLDDISALAKVVPVNGLVRNSDGSYSKSFNETIEY
YPLQLIVEDVKNKDERYIEKEPLPINKEFPKGSKVVFLGDYAYGGEATVD
GYNSETRLKLTVKKGSLRAEPNIGKVRAKLDSQALRFYPTQAAAAAAAAA
AAAAAAAAVADWLSEARKPFVVVSLESDSLTKASMAAVESEIIKYVSLPD
SSEQKKLAKVPREAILNAESSYVLLRSQRFHLGDRVMYIQDSGKVPLHSK
GTVVGYTSIGKNVSIQVLFDNEIIAGNNFGGRLQTRRGLGLDSSFLLNLS
DRQLVY
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3pif Chain B Residue 1254 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3pif Structural and biochemical studies of the 5' -> 3' exoribonuclease Xrn1.
Resolution2.92 Å
Binding residue
(original residue number in PDB)		Q178 D206 D208 D291
Binding residue
(residue number reindexed from 1)		Q157 D185 D187 D261
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.13.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0008409 5'-3' exonuclease activity
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3pif, PDBe:3pif, PDBj:3pif
PDBsum3pif
PubMed21297639
UniProtQ6CJ09

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