Structure of PDB 3pgd Chain B Binding Site BS01

Receptor Information
>3pgd Chain B (length=185) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGDTRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSDVGEYRA
VTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRRVEPKV
TVYPSKTNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTF
QTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3pgd Bidirectional binding of invariant chain peptides to an MHC class II molecule.
Resolution2.72 Å
Binding residue
(original residue number in PDB)		W9 F13 Y47 D57 Y60 W61 R71 T77 Y78 H81 N82
Binding residue
(residue number reindexed from 1)		W10 F14 Y48 D58 Y61 W62 R72 T78 Y79 H82 N83
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3pgd, PDBe:3pgd, PDBj:3pgd
PDBsum3pgd
PubMed21115828
UniProtP01911|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

[Back to BioLiP]