Structure of PDB 3pgc Chain B Binding Site BS01

Receptor Information

>3pgc Chain B (length=184) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GDTRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSDVGEYRAV
TELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRRVEPKVT
VYPSNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTL
VMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARS

Ligand information

>3pgc Chain C (length=15) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KMRMATPLLMQALPM

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	3pgc Bidirectional binding of invariant chain peptides to an MHC class II molecule.
Resolution	2.66 Å
Binding residue (original residue number in PDB)	W9 D57 Y60 W61 R71 Y78 H81 N82 V85
Binding residue (residue number reindexed from 1)	W9 D57 Y60 W61 R71 Y78 H81 N82 V85

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006955	immune response
GO:0019882	antigen processing and presentation

	Cellular Component
GO:0016020	membrane
GO:0042613	MHC class II protein complex

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3pgc, PDBe:3pgc, PDBj:3pgc
PDBsum	3pgc
PubMed	21115828
UniProt	P01911\|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

[Back to BioLiP]