Structure of PDB 3p35 Chain B Binding Site BS01
Receptor Information
>3p35 Chain B (length=222) Species:
9606
(Homo sapiens) [
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CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKY
GLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNS
LMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAI
ILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYG
CCKELASRLRYARTMVDKLLSS
Ligand information
>3p35 Chain E (length=6) [
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MQSSPL
Receptor-Ligand Complex Structure
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PDB
3p35
From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
Resolution
2.09 Å
Binding residue
(original residue number in PDB)
W414 D416 Y485 E488 H489 L490 L491 R516 F535 H538 K540
Binding residue
(residue number reindexed from 1)
W43 D45 Y114 E117 H118 L119 L120 R145 F164 H167 K169
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:3p35
,
PDBe:3p35
,
PDBj:3p35
PDBsum
3p35
PubMed
21472932
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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