Structure of PDB 3ow4 Chain B Binding Site BS01

Receptor Information
>3ow4 Chain B (length=318) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA
HTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER
VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDF
GLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM
CGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG
GGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT
AQMITRPHFPQFDYSASS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3ow4 Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H194 E234 F236 D274 K276 E278 F309 C310 G311 T312 E314
Binding residue
(residue number reindexed from 1)		H51 E91 F93 D131 K133 E135 F166 C167 G168 T169 E171
Enzymatic activity
Catalytic site (original residue number in PDB) D274 K276 N279 D292 T312
Catalytic site (residue number reindexed from 1) D131 K133 N136 D149 T169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3ow4, PDBe:3ow4, PDBj:3ow4
PDBsum3ow4
PubMed20971641
UniProtP31749|AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (Gene Name=AKT1)

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