Structure of PDB 3ovr Chain B Binding Site BS01

Receptor Information
>3ovr Chain B (length=220) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GCKIGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFVPNITFGHPV
VESLRKQLGQDPFFDMHMMVSKPEQWVKPMAVAGANQYTFHLEATENPGA
LIKDIRENGMKVGLAIKPGTSVEYLAPWANQIDMALVMTVEPGFGGQKFM
EDMMPKVHWLRTQFPSLDIEVDGGVGPDTVHKCAEAGANMIVSGSAIMRS
EDPRSVINLLRNVCSEAAQK
Ligand information
Ligand IDFE2
InChIInChI=1S/Fe/q+2
InChIKeyCWYNVVGOOAEACU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Fe+2]
CACTVS 3.341[Fe++]
FormulaFe
NameFE (II) ION
ChEMBL
DrugBankDB14510
ZINC
PDB chain3ovr Chain B Residue 229 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3ovr Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE
Resolution1.948 Å
Binding residue
(original residue number in PDB)		H35 D37 H70 D175
Binding residue
(residue number reindexed from 1)		H32 D34 H67 D172
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) S10 H35 D37 M39 H70 M72 M141 D175
Catalytic site (residue number reindexed from 1) S7 H32 D34 M36 H67 M69 M138 D172
Enzyme Commision number 5.1.3.1: ribulose-phosphate 3-epimerase.
Gene Ontology
Molecular Function
GO:0004750 D-ribulose-phosphate 3-epimerase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006098 pentose-phosphate shunt
GO:0009052 pentose-phosphate shunt, non-oxidative branch
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3ovr, PDBe:3ovr, PDBj:3ovr
PDBsum3ovr
PubMed20923965
UniProtQ96AT9|RPE_HUMAN Ribulose-phosphate 3-epimerase (Gene Name=RPE)

[Back to BioLiP]