Structure of PDB 3ojy Chain B Binding Site BS01

Receptor Information
>3ojy Chain B (length=504) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDC
VTNRPCRSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYK
KCQHEMDQYWGIGSLASGINLFTNSFEGPVLDHRYYAGGCSPHYILNTRF
RKPYNVESYTPQTQGKYEFILKEYESYSDFERNVTESGFSFGFKIPGIFE
LGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHY
EFLQRVKRLPLEYSYGEYRDLFRDFGTHYITEAVLGGIYEYTLVMNKEAM
ERGDYTLNNVHACAKNDSVGKCRGILNEIKDRNKRDTMVEDLVVLVRGGA
SEHITTLAYQELPTADLMQEWGDAVQYNPAIIKVKVEPLYELVTATDFAY
SSTVRQNMKQALEEFQKEVSSCHCAPCQGNGVPVLKGSRCDCICPVGSQG
LACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNSGPASE
TLDC
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3ojy Chain B Residue 538 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3ojy Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.
Resolution2.51 Å
Binding residue
(original residue number in PDB)		L84 N87 D89 D91 D97 E98
Binding residue
(residue number reindexed from 1)		L78 N81 D83 D85 D91 E92
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0044877 protein-containing complex binding
Biological Process
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0050778 positive regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome
GO:1903561 extracellular vesicle

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3ojy, PDBe:3ojy, PDBj:3ojy
PDBsum3ojy
PubMed21454577
UniProtP07358|CO8B_HUMAN Complement component C8 beta chain (Gene Name=C8B)

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