Structure of PDB 3ocb Chain B Binding Site BS01

Receptor Information
>3ocb Chain B (length=320) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA
HTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER
VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDF
GLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM
CGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG
GGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT
AQMITITRPHFPQFDYSASS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3ocb Discovery of pyrrolopyrimidine inhibitors of Akt.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		E234 F236 D274 K276 L277 E278 F309 C310 G311 T312 P313 E314 Y315 L316 E341 L347
Binding residue
(residue number reindexed from 1)		E91 F93 D131 K133 L134 E135 F166 C167 G168 T169 P170 E171 Y172 L173 E198 L204
Enzymatic activity
Catalytic site (original residue number in PDB) D274 K276 N279 D292 T312
Catalytic site (residue number reindexed from 1) D131 K133 N136 D149 T169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3ocb, PDBe:3ocb, PDBj:3ocb
PDBsum3ocb
PubMed20810279
UniProtP31749|AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (Gene Name=AKT1)

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