Structure of PDB 3ob2 Chain B Binding Site BS01

Receptor Information
>3ob2 Chain B (length=296) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEG
KMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKL
SLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKS
FRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSL
LRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWA
IGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3ob2 Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Resolution2.1 Å
Binding residue
(original residue number in PDB)		P81 Y274 R294 S296 C297 T298 Y307 Q316 T317 I318 K322 E334 Y337
Binding residue
(residue number reindexed from 1)		P27 Y220 R240 S242 C243 T244 Y253 Q262 T263 I264 K268 E280 Y283
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3ob2, PDBe:3ob2, PDBj:3ob2
PDBsum3ob2
PubMed20877636
UniProtP22681|CBL_HUMAN E3 ubiquitin-protein ligase CBL (Gene Name=CBL)

[Back to BioLiP]