Structure of PDB 3o6z Chain B Binding Site BS01

Receptor Information

>3o6z Chain B (length=188) Species: 83333 (Escherichia coli K-12)

QQITLIKDKILSDNYFTLHNITYDLTRKDGVIRHKREVYDRGNGATILLY
NTKKKTVVLIRQFRVATWVNGNESGQLIESCAGLLDNDEPEVCIRKEAIE
ETGYEVGEVRKLFELYMSPGGVTELIHFFIAEYSDNQRANAGGGVEDEAI
EVLELPFSQALEMIKTGEIRDGKTVLLLNYLQTSHLMD

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3o6z Chain B Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3o6z Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition.
• Resolution: 2.05 Å
• Binding residue (original residue number in PDB): E100 E104 E151
• Binding residue (residue number reindexed from 1): E97 E101 E148
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.1.-

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003824 catalytic activity
• GO:0016787 hydrolase activity
• GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
• GO:0042803 protein homodimerization activity
• GO:0046872 metal ion binding
• GO:0052751 GDP-mannose hydrolase activity

Biological Process

• GO:0006753 nucleoside phosphate metabolic process
• GO:0019693 ribose phosphate metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:3o6z, PDBe:3o6z, PDBj:3o6z
• PDBsum: 3o6z
• PubMed: 21638333
• UniProt: P37128|NUDK_ECOLI GDP-mannose pyrophosphatase (Gene Name=nudK)