Structure of PDB 3o05 Chain B Binding Site BS01

Receptor Information
>3o05 Chain B (length=261) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLKGGVIMDVVTPEQAKIAEKSGACAVMALESIPADMRKSGKVCRMSDPK
MIKDIMNSVSIPVMAKVRIGHFVEAQIIEALEVDYIDESEVLTPADWTHH
IEKDKFKVPFVCGAKDLGEALRRINEGAAMIRTKGEAGTGDVSEAVKHIR
RITEEIKACQQLKSEDDIAKVAEEMRVPVSLLKDVLEKGKLPVVNFAAGG
VATPADAALLMQLGCDGVFVGSGIFKSSNPVRLATAVVEATTHFDNPSKL
LEVSSDLGELM
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain3o05 Chain B Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3o05 Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1
Resolution2.2 Å
Binding residue
(original residue number in PDB)		I83 W111 H114 R136 R137 K148
Binding residue
(residue number reindexed from 1)		I69 W97 H100 R122 R123 K134
Annotation score3
Enzymatic activity
Enzyme Commision number 4.3.3.6: pyridoxal 5'-phosphate synthase (glutamine hydrolyzing).
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0016843 amine-lyase activity
GO:0036381 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0006543 glutamine catabolic process
GO:0008615 pyridoxine biosynthetic process
GO:0042819 vitamin B6 biosynthetic process
GO:0042823 pyridoxal phosphate biosynthetic process
GO:1901617 organic hydroxy compound biosynthetic process
Cellular Component
GO:1903600 glutaminase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3o05, PDBe:3o05, PDBj:3o05
PDBsum3o05
PubMed20919991
UniProtQ03148|SNZ1_YEAST Pyridoxal 5'-phosphate synthase subunit SNZ1 (Gene Name=SNZ1)

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