Structure of PDB 3nqw Chain B Binding Site BS01

Receptor Information
>3nqw Chain B (length=178) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATYPSAKFMECLQYAAFKHRQQRRKDPQETPYVNHVINVSTILSVEACIT
DEGVLMAALLHDVVEDTDASFEDVEKLFGPDVCGLVREVTDDKSLEKQER
KRLQIENAAKSSCRAKLIKLADKLDNLRDLQVNTPTGWTQERRDQYFVWA
KKVVDNLRGTNANLELKLDEIFRQRGLL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3nqw Chain B Residue 300 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3nqw A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses
Resolution2.9 Å
Binding residue
(original residue number in PDB)		H36 H62 D63 D123
Binding residue
(residue number reindexed from 1)		H35 H61 D62 D122
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.7.2: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase.
Gene Ontology
Molecular Function
GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0015971 guanosine tetraphosphate catabolic process
GO:0042594 response to starvation

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Molecular Function
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Biological Process
External links
PDB RCSB:3nqw, PDBe:3nqw, PDBj:3nqw
PDBsum3nqw
PubMed20818390
UniProtQ9VAM9|MESH1_DROME Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (Gene Name=Mesh1)

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