Structure of PDB 3ncu Chain B Binding Site BS01
Receptor Information
>3ncu Chain B (length=120) Species:
9606
(Homo sapiens) [
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ENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQF
SSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQT
LYSKWKDFHFEKIPFDPAEM
Ligand information
>3ncu Chain D (length=12) [
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gacgcuagcguc
............
Receptor-Ligand Complex Structure
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PDB
3ncu
Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I.
Resolution
2.55 Å
Binding residue
(original residue number in PDB)
C829 H830 H847 K851 F853 K858 K861 G874 I875 K888 K907 W908
Binding residue
(residue number reindexed from 1)
C26 H27 H44 K48 F50 K55 K58 G71 I72 K85 K104 W105
Binding affinity
PDBbind-CN
: Kd=29.2nM
Enzymatic activity
Enzyme Commision number
3.6.4.13
: RNA helicase.
External links
PDB
RCSB:3ncu
,
PDBe:3ncu
,
PDBj:3ncu
PDBsum
3ncu
PubMed
20581823
UniProt
O95786
|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)
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