Structure of PDB 3mpj Chain B Binding Site BS01

Receptor Information

>3mpj Chain B (length=393) Species: 897 (Desulfococcus multivorans)

MDFNLSKELQMLQKEVRNFVNKKIVPFADQWDNENHFPYEEAVRPMGELG
FFGTVIPEEYGGEGMDQGWLAAMIVTEEIARGSSALRVQLNMEVLGCAYT
ILTYGSEALKKKYVPKLSSAEFLGGFGITEPDAGSDVMAMSSTAEDKGDH
WLLNGSKTWISNAAQADVLIYYAYTDKAAGSRGLSAFVIEPRNFPGIKTS
NLEKLGSHASPTGELFLDNVKVPKENILGKPGDGARIVFGSLNHTRLSAA
AGGVGLAQACLDAAIKYCNERRQFGKPIGDFQMNQDMIAQMAVEVEAARL
LAYKAAAAKDEGRLNNGLDVAMAKYAAGEAVSKCANYAMRILGAYGYSTE
YPVARFYRDAPTYYMVEGSANICKMIIALDQLGVRKANRKGHH

Ligand information

>3mpj Chain Y (length=8) Species: 897 (Desulfococcus multivorans)

KGHHHHHH

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3mpj Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): H36 F37 Y39 A164 Q165 D167 N193
• Binding residue (residue number reindexed from 1): H36 F37 Y39 A164 Q165 D167 N193

Enzymatic activity

• Catalytic site (original residue number in PDB): I128 T129 T245 E367 L379
• Catalytic site (residue number reindexed from 1): I128 T129 T245 E367 L379
• Enzyme Commision number: 1.3.99.32: glutaryl-CoA dehydrogenase (acceptor).

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003995 acyl-CoA dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
• GO:0050660 flavin adenine dinucleotide binding

Biological Process

• GO:0009056 catabolic process

External links

• PDB: RCSB:3mpj, PDBe:3mpj, PDBj:3mpj
• PDBsum: 3mpj
• PubMed: 20486657
• UniProt: C3UVB0|ACD_DESML Glutaryl-CoA dehydrogenase (Gene Name=Acd)