Structure of PDB 3m5m Chain B Binding Site BS01

Receptor Information
>3m5m Chain B (length=197) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGE
VQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDL
VGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPI
SYLKGSAGGPLLCPAGHAVGIFRAAVSTRGVAKAVDFIPVESLETTM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3m5m Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		H1057 I1132 K1136 G1137 A1139 F1154 A1156 A1157 V1158 S1159 T1160 K1165
Binding residue
(residue number reindexed from 1)		H75 I150 K154 G155 A157 F172 A174 A175 V176 S177 T178 K183
Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 A1139
Catalytic site (residue number reindexed from 1) H75 D99 G155 A157
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3m5m, PDBe:3m5m, PDBj:3m5m
PDBsum3m5m
PubMed21084633
UniProtA8DG50

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