Structure of PDB 3lqj Chain B Binding Site BS01
Receptor Information
>3lqj Chain B (length=175) Species:
9606
(Homo sapiens) [
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SGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLP
ESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYQ
QPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSM
VKSFFIRQMERVFPWFSVKKSRFWE
Ligand information
>3lqj Chain T (length=6) Species:
9606
(Homo sapiens) [
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ARTKQT
Receptor-Ligand Complex Structure
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PDB
3lqj
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
Y1576 D1578 D1580 Y1581 S1583 M1585 M1586 Q1587 W1594 Y1607 E1608 S1611 V1617
Binding residue
(residue number reindexed from 1)
Y12 D14 D16 Y17 S19 M21 M22 Q23 W30 Y43 E44 S47 V53
Enzymatic activity
Enzyme Commision number
2.1.1.-
2.1.1.364
: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB
RCSB:3lqj
,
PDBe:3lqj
,
PDBj:3lqj
PDBsum
3lqj
PubMed
20541251
UniProt
Q03164
|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)
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