Structure of PDB 3lqi Chain B Binding Site BS01
Receptor Information
>3lqi Chain B (length=177) Species:
9606
(Homo sapiens) [
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SGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLP
ESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYR
QQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANS
MVKSFFIRQMERVFPWFSVKKSRFWEP
Ligand information
>3lqi Chain S (length=7) Species:
9606
(Homo sapiens) [
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ARTKQTA
Receptor-Ligand Complex Structure
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PDB
3lqi
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.
Resolution
1.92 Å
Binding residue
(original residue number in PDB)
D1580 Y1581 S1583 M1585 M1586 Q1587 W1594 Y1607 E1608 S1611 V1617
Binding residue
(residue number reindexed from 1)
D16 Y17 S19 M21 M22 Q23 W30 Y43 E44 S47 V53
Enzymatic activity
Enzyme Commision number
2.1.1.-
2.1.1.364
: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB
RCSB:3lqi
,
PDBe:3lqi
,
PDBj:3lqi
PDBsum
3lqi
PubMed
20541251
UniProt
Q03164
|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)
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