Structure of PDB 3lmk Chain B Binding Site BS01

Receptor Information

>3lmk Chain B (length=439) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHT
LERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDKPIVGVIGPG
SSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQAR
AMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGISIAHSYKIYS
NAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFL
LLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNH
RNPWFQEFWQHRFQCRLEGKYNKTCNSSLTLKTHHVQDSKMGFVINAIYS
MAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILF
DENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

3lmk Chain B Residue 506 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3lmk Metabotropic Glutamate receptor mGluR5 complexed with glutamate
Resolution	2.44 Å
Binding residue (original residue number in PDB)	I79 N80 L85 L86
Binding residue (residue number reindexed from 1)	I54 N55 L60 L61
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3lmk, PDBe:3lmk, PDBj:3lmk
PDBsum	3lmk
PubMed
UniProt	P41594\|GRM5_HUMAN Metabotropic glutamate receptor 5 (Gene Name=GRM5)

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