Structure of PDB 3lg2 Chain B Binding Site BS01

Receptor Information
>3lg2 Chain B (length=269) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLTPRCIIVRHGQTEWSKSGQYTGLTDLPLTPYGEGQMLRTGESVFRNNQ
FLNPDNITYIFTSPRLRARQTVDLVLKPLSDEQRAKIRVVVDDDLREWEY
GDYEGMLTREIIELRKSRGLDKERPWNIWRDGCENGETTQQIGLRLSRAI
ARIQNLHRKHQSEGRASDIMVFAHGHALRYFAAIWFGLGVQKKCETIEEI
QNVKSYDDDTVPYVKLESYRHLVDNPCFLLDAGGIGVLSYAHHNIDEPAL
ELAGPFVSPPEEESQHGDV
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain3lg2 Chain B Residue 300 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3lg2 Structure and activity of the metal-independent fructose-1,6-bisphosphatase YK23 from Saccharomyces cerevisiae.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H178 R181
Binding residue
(residue number reindexed from 1)		H176 R179
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H13 R69 E99
Catalytic site (residue number reindexed from 1) H11 R67 E97
Enzyme Commision number 3.1.3.37: sedoheptulose-bisphosphatase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016787 hydrolase activity
GO:0050278 sedoheptulose-bisphosphatase activity
Biological Process
GO:0046390 ribose phosphate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3lg2, PDBe:3lg2, PDBj:3lg2
PDBsum3lg2
PubMed20427268
UniProtP36136|SHB17_YEAST Sedoheptulose 1,7-bisphosphatase (Gene Name=SHB17)

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