Structure of PDB 3kql Chain B Binding Site BS01

Receptor Information
>3kql Chain B (length=437) Species: 333284 (Hepatitis C virus (isolate Con1)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGF
GAYMSKAHGIDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIII
CDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEE
VALSSTGEIPFYGKAIPIETIKGGRHLIFCHSKKKCDELAAKLSGLGLNA
VAYYRGLDVSVIPTSGDVIVVATDALMTGFTGDFDSVIDCNTCVTQTVDF
SLDPTFTIETTTVPQDAVSRSQRRGRTGRGRMGIYRFVTPGERPSGMFDS
SVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTG
LTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRL
KPTLHGPTPLLYRLGAVQNEVTTTHPITKYIMACMSA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3kql Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		P230 V232 T254 G255 T269 S370 K371 R393 T411 A413 V432 T448 W501 Y502 N556
Binding residue
(residue number reindexed from 1)		P42 V44 T66 G67 T81 S182 K183 R205 T223 A225 V244 T260 W313 Y314 N368
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:3kql, PDBe:3kql, PDBj:3kql
PDBsum3kql
PubMed20080715
UniProtQ9WMX2|POLG_HCVCO Genome polyprotein

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