Structure of PDB 3kf2 Chain B Binding Site BS01

Receptor Information

>3kf2 Chain B (length=181) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCING
VCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHA
VGLFRAAVCTRGVAKAVDFIPVENLETTMRS

Ligand information

>3kf2 Chain C (length=16) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GSVVIVGRIVLSGKPA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3kf2 Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target
Resolution	2.5 Å
Binding residue (original residue number in PDB)	T4 A5 Y6 A7
Binding residue (residue number reindexed from 1)	T4 A5 Y6 A7

Enzymatic activity

Enzyme Commision number

3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis
GO:0019087	transformation of host cell by virus

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Molecular Function

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Biological Process

External links

PDB	RCSB:3kf2, PDBe:3kf2, PDBj:3kf2
PDBsum	3kf2
PubMed	20166108
UniProt	B2Y2M9

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