Structure of PDB 3k0s Chain B Binding Site BS01

Receptor Information
>3k0s Chain B (length=753) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LRLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTPMAGIPYHAVE
NYLAKLVNQGESVAICEQERKVVRIVTPGTISDEALLQERQDNLLAAIWQ
DSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMS
LIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAG
CLLQYAKDTQRTTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAE
NTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAGL
QPVLRQVGDLERILARLALRTARPRDLARMRHAFQQLPELRAQLETVDSA
PVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRA
LADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQSHLAPIN
YMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPH
LEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVV
EQVLNEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGS
YVPAQKVEIGPIDRIFTRVGSTFMVEMTETANILHNATEYSLVLMNEIGR
GTSTYDGLSLAWACAENLANKIKALTLFATHYFELTQLPEKMEGVANVHL
DALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELE
SIS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3k0s Magnesium coordination controls the molecular switch function of DNA mismatch repair protein MutS.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		Q95 N468 L495 K496 R500
Binding residue
(residue number reindexed from 1)		Q68 N430 L457 K458 R462
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008301 DNA binding, bending
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0032136 adenine/cytosine mispair binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006974 DNA damage response
Cellular Component
GO:0005829 cytosol
GO:0032300 mismatch repair complex
GO:1990710 MutS complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3k0s, PDBe:3k0s, PDBj:3k0s
PDBsum3k0s
PubMed20167596
UniProtP23909|MUTS_ECOLI DNA mismatch repair protein MutS (Gene Name=mutS)

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