Structure of PDB 3jwh Chain B Binding Site BS01
Receptor Information
>3jwh Chain B (length=188) Species:
240292
(Trichormus variabilis ATCC 29413) [
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SLNQQRMNGVVAALKQSNARRVIDLGCGQGNLLKILLKDSFFEQITGVDV
SYRSLEIAQERLDRLRLPRNQWERLQLIQGALTYQDKRFHGYDAATVIEV
IEHLDLSRLGAFERVLFEFAQPKIVIVTTPNIEYNVKFRFEWTRSQFQNW
ANKITERFAYNVQFQPIGEADPEVGSPTQMAVFIHRGH
Ligand information
Ligand ID
SAH
InChI
InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChIKey
ZJUKTBDSGOFHSH-WFMPWKQPSA-N
SMILES
Software
SMILES
CACTVS 3.341
N[CH](CCSC[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23)C(O)=O
OpenEye OEToolkits 1.5.0
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O)N
CACTVS 3.341
N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23)C(O)=O
ACDLabs 10.04
O=C(O)C(N)CCSCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0
c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N
Formula
C14 H20 N6 O5 S
Name
S-ADENOSYL-L-HOMOCYSTEINE
ChEMBL
CHEMBL418052
DrugBank
DB01752
ZINC
ZINC000004228232
PDB chain
3jwh Chain B Residue 1 [
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Receptor-Ligand Complex Structure
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PDB
3jwh
Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
G288 D311 V312 A343 L344
Binding residue
(residue number reindexed from 1)
G26 D49 V50 A81 L82
Annotation score
5
Enzymatic activity
Enzyme Commision number
2.1.1.386
: small RNA 2'-O-methyltransferase.
Gene Ontology
Molecular Function
GO:0008171
O-methyltransferase activity
GO:0008173
RNA methyltransferase activity
Biological Process
GO:0001510
RNA methylation
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:3jwh
,
PDBe:3jwh
,
PDBj:3jwh
PDBsum
3jwh
PubMed
19822745
UniProt
Q3MCR9
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