Structure of PDB 3jvf Chain B Binding Site BS01

PDB	3jvf Structural basis of receptor sharing by interleukin 17 cytokines.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	N43 E45
Binding residue (residue number reindexed from 1)	N19 E21
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005515	protein binding
GO:0019955	cytokine binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

	Biological Process
GO:0001819	positive regulation of cytokine production
GO:0002225	positive regulation of antimicrobial peptide production
GO:0002250	adaptive immune response
GO:0006954	inflammatory response
GO:0016525	negative regulation of angiogenesis
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0032645	regulation of granulocyte macrophage colony-stimulating factor production
GO:0032663	regulation of interleukin-2 production
GO:0032675	regulation of interleukin-6 production
GO:0032677	regulation of interleukin-8 production
GO:0032755	positive regulation of interleukin-6 production
GO:0032761	positive regulation of lymphotoxin A production
GO:0045087	innate immune response
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0051216	cartilage development
GO:0097400	interleukin-17-mediated signaling pathway
GO:1900017	positive regulation of cytokine production involved in inflammatory response
GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space

External links

PDB	RCSB:3jvf, PDBe:3jvf, PDBj:3jvf
PDBsum	3jvf
PubMed	19838198
UniProt	Q96PD4\|IL17F_HUMAN Interleukin-17F (Gene Name=IL17F)