Structure of PDB 3jrd Chain B Binding Site BS01

Receptor Information
>3jrd Chain B (length=98) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDL
YELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3jrd The shape of the DNA minor groove directs binding by the DNA-bending protein Fis.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		N73 Q74 T75 R85 R89
Binding residue
(residue number reindexed from 1)		N73 Q74 T75 R85 R89
Binding affinityPDBbind-CN: Kd=1nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001216 DNA-binding transcription activator activity
GO:0001217 DNA-binding transcription repressor activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0044374 sequence-specific DNA binding, bending
Biological Process
GO:0006351 DNA-templated transcription
GO:0006355 regulation of DNA-templated transcription
GO:0009314 response to radiation
GO:0032359 provirus excision
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:0045911 positive regulation of DNA recombination
GO:0051276 chromosome organization
Cellular Component
GO:0000786 nucleosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009295 nucleoid
GO:0031421 invertasome
GO:0032993 protein-DNA complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3jrd, PDBe:3jrd, PDBj:3jrd
PDBsum3jrd
PubMed20395367
UniProtP0A6R3|FIS_ECOLI DNA-binding protein Fis (Gene Name=fis)

[Back to BioLiP]