Structure of PDB 3jcm Chain B Binding Site BS01

Receptor Information
>3jcm Chain B (length=429) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NESTADILKQLPHERLQAVLEKIPEEDLEVRRLLSILKKPEVVENEDVQQ
RRIRLAEILMVDEIDLENINNDFFTPATSELIFARRFLINYSLERSRKRL
QKEMERHQKFNTRQELLSRRTELQRMANLELAGSQLVSTKPISAVSLSTD
DMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMIS
CAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHD
MTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDI
RSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQL
NQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGH
TDKIISLDISNNSHFLVSGGWDRSIKLWN
Ligand information
>3jcm Chain D (length=45) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aauacagagaucagcaguuccccugcauaaggaugaaccguguuu
.............................................
Receptor-Ligand Complex Structure
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PDB3jcm The 3.8 angstrom structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
Resolution3.8 Å
Binding residue
(original residue number in PDB)		N66 E67
Binding residue
(residue number reindexed from 1)		N45 E46
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030621 U4 snRNA binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000393 spliceosomal conformational changes to generate catalytic conformation
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0034247 snoRNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005687 U4 snRNP
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3jcm, PDBe:3jcm, PDBj:3jcm
PDBsum3jcm
PubMed26743623
UniProtP20053|PRP4_YEAST U4/U6 small nuclear ribonucleoprotein PRP4 (Gene Name=PRP4)

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