Structure of PDB 3j7a Chain B Binding Site BS01

Receptor Information

>3j7a Chain B (length=210) Species: 36329 (Plasmodium falciparum 3D7)

FTKKEWYDLKAPKMFLVRNFGKTLVTKTIGKKLATDSLKGRIYEVNLADL
NNDEDQAHKKIKLSCDHIINRDCYTDFCGLSITRDKLCSLIRKGYTLIEG
HTDVKTLDNYHLRMFCIAFTKKRQNQTKSTCYAQTSQIKKIRKKMVDIMT
AEASKVLLKDLVKKFIPESIGKEIEKQCKKIYPLQNVLIRKVKILKRPKL
DISKLMELHT

Ligand information

>3j7a Chain A (length=1608)

aaccugguugaucuugccaguagucauaugcuugucucaaagauuaagcc
augcaagugaaaguauauauauauauauguagaaacugcgaacggcucau
uaaaacaguuauagucuacuugacauuuauaaggauaacuacggaaaagc
uguagcuaauacuugcauuauccuuuuggauaaguauuuguuagaaggaa
uuauaacaaagaaguaacacguaaaguguguaucaaucgaguuucugacc
uaucagcuuuugauguuaggguauuggccuaacauggcuaugacggguaa
cggggaauuagaguucgauuccggagagggagccugagaaauagcuacca
caucuaaggaaggcagcaggcgcguaaauuacccaauucuaaagaagaga
gguagugacaagaaauaacaaugcaagguuuguauuggaauggugggaau
uuaaaaccuucccagaguaacaauuggagggcaagucuggugccagcagc
cgcgguaauuccagcuccaauagcguauauuaaaauuguugcaguuaaaa
cgcucguaguugaauuucaaagaaucauucuuuuuaaaauccggauuugu
uacuuugaguaaauuagaguguucaaagcaaacaguuaaagcauuguguu
ugaauacuauagcauggaauaacaaaauugaacaagcuaaaauuuuuugu
ucuuauuuuggcuuaguuacgauuaauaggaguagcuuggggacauucgu
auucagaugucagaggugaaauucuuagauuuucuggagacgaacaacug
cgaaagcauuugucuaaaauacuuccauuaaucaagaacgaaaguuaagg
gagugaagacgaucagauaccgucguaaucuuaaccauaaacuaugccga
cuagguguuggaugaagugcuuccuucaguaccuuaugagaaaucaaagu
cuuuggguucuggggcgaguauucgcgcaagcgagaaaguuaaaagaauu
gacggaagggcaccaccaggcguggagcuugcggcuuaauuugacucaac
acggggaaacucacuaguuuaagacauuggauggugaugcauggccguuu
uuaguucgugaaugauuugucugguuaauuccgauaacgaacgagaucuu
aaccugcuaauuagcggcgaguacacuguacuugcugcuucuuagaggaa
cauugugugucuaacacaaggaaguuuaaggcaacaacaggucugugaug
uccuuagaugaacuaggcugcacgcgugcuacacugauauauauaacgag
uaaaauaugcuugcauacuuuuccuccgccgaaaggcguagguaaucuuu
aucaauauauaucgugauggggauagauuauugcaauuauuaaucuugaa
cgaggaaugccuaguaagcaugauucaucagauugugcugacuacguccc
ugcccuuuguacacaccgcccgucgcuccuaccgauugaaagauaugaug
aauuguuuggacaagaaaaauuuuuucuggaaaaaccguaaauccuaucu
uuuaaaggaaggagaagucguaacaagguuuccguaggugaaccugcgga
aggaucau

...<<<<<.[.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<...<<<<<<..>>>>>>...>>.>>......<<..<
.....<<<..<<..<<...<<<<........<<.....<<<<<<.....>
>>>>>......>>....<<<<<<....>>>>>>...<<<<<<<.<.....
.>.>>>>>>>.......<<<.....>>>....>>>>..>>>>..>>>.<<
<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...
<<<<<<<<....>>>>...>>>>>>>.<<.<<<..........>>>.>>.
<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..
>>>..>....>>>.....<<<<<<<<<.>>>>>>>>>......<<<<<<.
........>>>>>>.........<<<<<((....<.<<<<.....<<..)
)>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((....
.<.<<...<<<.<<....<<<<.<....>.>>>>..<<<<<..>>>>><<
<<<<.<<.......<<...<.......>.<<<<.......<<<.>>>>>>
>...>>......>>.>>..>>>>.....<.<<<.<<.<.<<<.<......
....>.>>>.>.>>.>>>..>.>>....<<<<<<..<<..<<<<<..<<<
.<<<<<<.<...<<<......>>>......>.>>>>>.>>>>.......<
<....>>...>>>>>.>>.>>>.>>>...>>>...>>.>....<<<<<<.
..<<...<<<<.........>>>>...>>>>>>>>..........<<<.<
<.<<<<<<<<<<.<<<<..>>>>.>>>>>>>>>>...<<..))>>...>>
.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<
<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<.......
.>>..........<<<<<<<....<...>...<<.<<<..<<<<<<<<<.
...<<<<<<<<<...>>>...<<<......>>>...>>>>>>....<<<<
<.<<<..<<<..<<<<<<<<<<<<...>>>>>>>>>>>>..>>>.>>>..
..<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>
>>>>.....>>>>>>>...>>.>>>>.>>>.....<<<<<<<<.....<<
.<<<.<<<<<..>>>>>.>.>><<<.<<<<....>>>>.>>>....>>..
.....>>>>>>>>...........<<<<<<..........>>>>>>....
......>>>>>>....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<.
.<<.<<<<...<<.<<<<<.>>>.>>.>>...>>>>.>>..>>>.>>>>>
>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>
>.......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3j7a Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): K27 I114 K116 L120 E122 H124 R136 F138 R146 N148 Y155 Q157 T158 S159 K162 R165 K214 K216
• Binding residue (residue number reindexed from 1): K4 I91 K93 L97 E99 H101 R113 F115 R123 N125 Y132 Q134 T135 S136 K139 R142 K191 K193

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:3j7a, PDBe:3j7a, PDBj:3j7a
• PDBsum: 3j7a
• PubMed: 24913268
• UniProt: O97313|RS3A_PLAF7 Small ribosomal subunit protein eS1 (Gene Name=RPS3A)