Structure of PDB 3ipu Chain B Binding Site BS01

Receptor Information
>3ipu Chain B (length=235) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPSREARQQRFAHFTEL
AIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGS
ESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMK
LVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDV
Ligand information
Receptor-Ligand Complex Structure
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PDB3ipu X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		V269 K273 R283 E284 I287 A288 K291 P437 E441
Binding residue
(residue number reindexed from 1)		V59 K63 R73 E74 I77 A78 K81 P227 E231
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3ipu, PDBe:3ipu, PDBj:3ipu
PDBsum3ipu
PubMed20382159
UniProtQ13133|NR1H3_HUMAN Oxysterols receptor LXR-alpha (Gene Name=NR1H3)

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