Structure of PDB 3ihp Chain B Binding Site BS01

Receptor Information
>3ihp Chain B (length=681) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLYICMNTF
LGFGKQYVERHFNKTGQRVYLHLRRTDEDVKIVILPDYLEIARDGLGGLP
DIVRDRVTSAVEALLSVRQVSKHAFSLKQLDNPARIPPCGWKCSKCDMRE
NLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGA
DVYSYDEDDMVLDPSLAEHLSHFGIDMPLKPLFGPGYTGIRNLGNSCYLN
SVVQVLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGLLSGE
GIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNCRSSENPNEV
FRFLVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEKKR
QAEEEKMALPELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTT
RFASFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRGTGLQPG
EEELPDILDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMD
DPDFANPLILDPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIF
SHIDDLDAEAAMDGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEG
RWVIYNDQKVCASEKPPKDLGYIYFYQRVAS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3ihp Chain B Residue 836 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3ihp Covalent Ubiquitin-Usp5 Complex
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C199 C202 H232
Binding residue
(residue number reindexed from 1)		C143 C146 H176
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008270 zinc ion binding
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
GO:0101005 deubiquitinase activity
Biological Process
GO:0006508 proteolysis
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108 protein K48-linked deubiquitination
GO:0140251 regulation protein catabolic process at presynapse
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005829 cytosol
GO:0098793 presynapse

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3ihp, PDBe:3ihp, PDBj:3ihp
PDBsum3ihp
PubMed
UniProtP45974|UBP5_HUMAN Ubiquitin carboxyl-terminal hydrolase 5 (Gene Name=USP5)

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