Structure of PDB 3ie0 Chain B Binding Site BS01

Receptor Information

>3ie0 Chain B (length=431) Species: 300852 (Thermus thermophilus HB8)

MRIVPFGAAREVTGSAHLLLAGGRRVLLDCGMFQGKEEARNHAPFGFDPK
EVDAVLLTHAHLDHVGRLPKLFREGYRGPVYATRATVLLMEIVLEDALKV
MDEPFFGPEDVEEALGHLRPLEYGEWLRLGALSLAFGQAGHLPGSAFVVA
QGEGRTLVYSGDLGNREKDVLPDPSLPPLADLVLAEGTYGDRPHRPYRET
VREFLEILEKTLSQGGKVLIPTFAVERAQEILYVLYTHGHRLPRAPIYLD
SPMAGRVLSLYPRLVRYFSEEVQAHFLQGKNPFRPAGLEVVEHTEASKAL
NRAPGPMVVLAGSGMLAGGRILHHLKHGLSDPRNALVFVGYQPQGGLGAE
IIARPPAVRILGEEVPLRASVHTLGGFYGHAGQDELLDWLQGEPRVVLVH
GEEEKLLALGKLLALRGQEVSLARFGEGVPV

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 3ie0 Chain B Residue 452

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3ie0 Crystal Structure of S378Y mutant TTHA0252 from Thermus thermophilus HB8
• Resolution: 2.73 Å
• Binding residue (original residue number in PDB): D63 H64 D162 H400
• Binding residue (residue number reindexed from 1): D63 H64 D162 H400
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0004521 RNA endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006364 rRNA processing

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3ie0, PDBe:3ie0, PDBj:3ie0
• PDBsum: 3ie0
• UniProt: Q5SLP1|RNSE_THET8 Ribonuclease TTHA0252 (Gene Name=TTHA0252)