Structure of PDB 3hvr Chain B Binding Site BS01

Receptor Information
>3hvr Chain B (length=657) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRA
GGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDP
GERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVL
DLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWE
LLRLGEEDPKELPLPSLLDYHASKGRLQGREGGRVAWVADRKPIPHLTGL
LVPVLTLELSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPK
LMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFG
ASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNR
LKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYP
AELAVGFDAGESFRFGGAACAVGGDHLLWTLPEAQAGERIPQEVVWDLLE
ETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVR
KSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHGTPRPLKLVHEAGDTPL
EALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVD
REKLFFV
Ligand information
Receptor-Ligand Complex Structure
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PDB3hvr Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Resolution3.211 Å
Binding residue
(original residue number in PDB)		A170 R172 T201 S280 M413 W415 R418 K422 Q433 I434 N436 R446 N449 K457 E512 R513 Q551 R580 T613 R651 H657 R661
Binding residue
(residue number reindexed from 1)		A167 R169 T198 S260 M393 W395 R398 K402 Q413 I414 N416 R426 N429 K437 E488 R489 Q527 R556 T585 R623 H629 R633
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3hvr, PDBe:3hvr, PDBj:3hvr
PDBsum3hvr
PubMed19812667
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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