Structure of PDB 3hk2 Chain B Binding Site BS01

Receptor Information
>3hk2 Chain B (length=666) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRA
GGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDP
GERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVL
DLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWE
LLRLGEEDPKELPLPSLLDYHASKGRLQGREGGRVAWVADPKDPRKPIPH
LTGLLVPVLTLESLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLS
IPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLR
AFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWED
RNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSG
AYPAELAVGFNAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQE
VVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIA
YDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRRGTPRPLKL
VHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRL
GIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3hk2 Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Y43 R59 A170 Y171 R172 T266 M413 W415 K422 Q433 I434 N436 R446 N449 E512 R513 R548 P550 Q551 R580 T613 R615 A644 S645 R651 H657 R661 V685
Binding residue
(residue number reindexed from 1)		Y40 R56 A167 Y168 R169 T260 M396 W398 K405 Q416 I417 N419 R429 N432 E495 R496 R531 P533 Q534 R563 T594 R596 A625 S626 R632 H638 R642 V666
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3hk2, PDBe:3hk2, PDBj:3hk2
PDBsum3hk2
PubMed19812667
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

[Back to BioLiP]