Structure of PDB 3haj Chain B Binding Site BS01

Receptor Information
>3haj Chain B (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSFWEVGNYKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLTEWARR
WRQLVEKGPQYGTVEKAWMAFMSEAERVSELHLEVKASLMNDDFEKIKNW
QKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAACKE
EKLAISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKEKYEKSLKEL
DQGTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVAGYKA
IYHDLEQSIRAADAVEDLRWFRANHGPGMAMNWP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3haj Chain B Residue 488 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3haj Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		V71 E72 G74 Q76 Y77 E81
Binding residue
(residue number reindexed from 1)		V55 E56 G58 Q60 Y61 E65
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008092 cytoskeletal protein binding
GO:0008289 lipid binding
GO:0042802 identical protein binding
GO:0045296 cadherin binding
GO:0070300 phosphatidic acid binding
Biological Process
GO:0006897 endocytosis
GO:0007010 cytoskeleton organization
GO:0030036 actin cytoskeleton organization
GO:0030100 regulation of endocytosis
GO:0036010 protein localization to endosome
GO:0045806 negative regulation of endocytosis
GO:0048858 cell projection morphogenesis
GO:0050804 modulation of chemical synaptic transmission
GO:0070836 caveola assembly
GO:0072584 caveolin-mediated endocytosis
GO:0097320 plasma membrane tubulation
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0016607 nuclear speck
GO:0032587 ruffle membrane
GO:0034451 centriolar satellite
GO:0042995 cell projection
GO:0043231 intracellular membrane-bounded organelle
GO:0055038 recycling endosome membrane
GO:0070062 extracellular exosome
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3haj, PDBe:3haj, PDBj:3haj
PDBsum3haj
PubMed19549836
UniProtQ9UNF0|PACN2_HUMAN Protein kinase C and casein kinase substrate in neurons protein 2 (Gene Name=PACSIN2)

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