Structure of PDB 3h8v Chain B Binding Site BS01

Receptor Information
>3h8v Chain B (length=222) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDLSKVQAAEHTLRN
INPDVLFEVHNYNITTVENFQHFMDRISNGGLEEGKPVDLVLSCVDNFEA
RMTINTACNELGQTWMESGVSENAVSGHIQLIIPGESACFACAPPLVVAA
VCAASLPTTMGVVAGILVQNVLKFLLNFGTVSFYLGYNAMQDFFPTMSMK
PNPQCDDRNCRKQQEEYKKKVA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3h8v Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3h8v Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		C226 C229 C303 C308
Binding residue
(residue number reindexed from 1)		C139 C142 C205 C210
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.7.-
Gene Ontology
Molecular Function
GO:0008641 ubiquitin-like modifier activating enzyme activity

View graph for
Molecular Function
External links
PDB RCSB:3h8v, PDBe:3h8v, PDBj:3h8v
PDBsum3h8v
PubMed20368332
UniProtQ9GZZ9|UBA5_HUMAN Ubiquitin-like modifier-activating enzyme 5 (Gene Name=UBA5)

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