Structure of PDB 3h5n Chain B Binding Site BS01

Receptor Information

>3h5n Chain B (length=338) Species: 562 (Escherichia coli)

MDYILGRYVKIARYGSGGLVGGGGKEQYVENLVLWENIIKTAYCFITPSS
YTAALETANIPEKDFSNCFRFLKENFFIIPGEYNNSTENNRYSRNFLHYQ
SYGANPVLVQDKLKNAKVVILGCGGIGNHVSVILATSGIGEIILIDNDQI
ENTNLTRQVLFSEDDVGKNKTEVIKRELLKRNSEISVSEIALNINDYTDL
HKVPEADIWVVSADHPFNLINWVNKYCVRANQPYINAGYVNDIAVFGPLY
VPGKTGCYECQKKENIDHKIKLINSRFKPATFAPVNNVAAALCAADVIKF
IGKYSEPLSLNKRIGIWSDEIKIHSQNMGRSPVCSVCG

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 3h5n Chain B Residue 500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3h5n How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): C257 C260 C343 C346
• Binding residue (residue number reindexed from 1): C257 C260 C334 C337
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): R157
• Catalytic site (residue number reindexed from 1): R157

Gene Ontology

Molecular Function

• GO:0004792 thiosulfate sulfurtransferase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0008641 ubiquitin-like modifier activating enzyme activity
• GO:0016779 nucleotidyltransferase activity
• GO:0046872 metal ion binding

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3h5n, PDBe:3h5n, PDBj:3h5n
• PDBsum: 3h5n
• PubMed: 19494832
• UniProt: Q47506