Structure of PDB 3h0g Chain B Binding Site BS01

Receptor Information
>3h0g Chain B (length=1150) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETLTQEDCWTVISSFFEETSLARQQLFSFDEFVQNTMQEIVDDDSTLTIN
FGQIYLSRPTMTEADGSTTTMFPQEARLRNLTYSSPLYVDMRKEDEEPSK
VFIGKIPIMLRSTFCILNGVSDSELYDLNECPYDQGGYFIINGSEKVIIA
QERSAANIVQVFKKAAPSPIAYVAEIRSALERGSRLISSMQIKLMARNTE
NSGQTIRATLPYIRSDIPIVIVFRALGVVPDRDILEHICYDPNDFQMLEM
MKPCIEEAFVIQDKDIALDYIGKRGSTTGVTREKRLRYAHDILQKELLPH
ITTMEGFETRKAFFLGYMIHRMLLCALERREPDDRDHFGKKRLDLAGPLL
ASLFRMLFRKMTRDVYKYMQKCVETNREFNLTLAVKSNIITNGLRYSLAT
GNWGDQKRSMVNRVGVSQVLNRYTFASTLSHLRRTNTPIGRDGKLAKPRQ
LHNTHWGMVCPAETPEGQACGLVKNLSLMSYVSVGSPSAPIIEFLEEWGL
ETLEDYNPSASPNATKVFVNGVWLGVHRDPAHLTETLRSLRRRLDISAEV
SIVRDIREKELRLFTDAGRICRPLFIVDNNPNSERRGELCIRKEHIQQLI
EDKDRYDIDPEQRFGWTALVSSGLIEYLDAEEEETVMIAMSPEDLEASRQ
MQAGYEVKEELDPAQRVKPAPNPHVHAWTHCEIHPAMILGILASIIPFPD
HNQSPRNTYQSAMGKQAMGVYLTNYQVRMDTMANILYYPQKPLATTRSME
YLKFRELPAGQNAIVAILCYSGYNQEDSIIMNQASIDRGLFRSIFYRTYT
DQEKKIGMTVMEEFERPVRSTTLRMKHGTYDKLEDDGLIAPGTRVSGEDI
IIGKTAPIQLHAKRDVSTPLRSTESGIVDQVMVTTNQEGLKFVKVRMRST
RIPQIGDKFASRHGQKGTIGMTYRHEDMPFSAQGIVPDIIINPHAIPSRM
TVAHLVECQLSKVSALSGFEGDATPFTDVTVEAVSKLLRSHGFQSRGFEV
MYHGHTGRKLVAQVFLGPTYYQRLKHLVDDKIHARARGPVQILTRQPVEG
RSRDGGLRFGEMERDCQISHGCSSVLRERLFDCSDAYRVIVCDICGLIAI
ASYKKDSYECRSCQNRTRFSQVYLPYAAKLLFQELMSMNIAPRLFTKNHK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3h0g Chain B Residue 2225 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3h0g Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution.
Resolution3.65 Å
Binding residue
(original residue number in PDB)		C1152 C1173
Binding residue
(residue number reindexed from 1)		C1092 C1113
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin
GO:0005829 cytosol
GO:0016591 RNA polymerase II, holoenzyme

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3h0g, PDBe:3h0g, PDBj:3h0g
PDBsum3h0g
PubMed19458260
UniProtQ02061|RPB2_SCHPO DNA-directed RNA polymerase II subunit RPB2 (Gene Name=rpb2)

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