Structure of PDB 3gv8 Chain B Binding Site BS01

Receptor Information
>3gv8 Chain B (length=374) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCRKPHTVRLIIRRYGRESRQCPIPSHVIQKDVMTPMVDILMKL
FRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB3gv8 Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Q59 K60 Y61 L62 L78 E97 L99 P299 Q300 S301 F302 S303 E304 E305 S307 R331 R347
Binding residue
(residue number reindexed from 1)		Q34 K35 Y36 L37 L53 E72 L74 P274 Q275 S276 F277 S278 E279 E280 S282 R306 R319
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3gv8, PDBe:3gv8, PDBj:3gv8
PDBsum3gv8
PubMed19440206
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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