Structure of PDB 3gpq Chain B Binding Site BS01
Receptor Information
>3gpq Chain B (length=160) Species:
371094
(Chikungunya virus strain S27-African prototype) [
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APSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSAT
PVGTAKTVMCGTYPVIHAVGPNFSNYSESEGDRELAAAYREVAKEVTRLG
VNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEK
KISEAIQMRT
Ligand information
>3gpq Chain F (length=2) [
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aa
..
Receptor-Ligand Complex Structure
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PDB
3gpq
The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
M9 D10 I11 G32 V33 T111 G112 V113 C143 R144 D145 W148
Binding residue
(residue number reindexed from 1)
M9 D10 I11 G32 V33 T111 G112 V113 C143 R144 D145 W148
Enzymatic activity
Enzyme Commision number
2.1.1.-
2.7.7.-
2.7.7.19
: polynucleotide adenylyltransferase.
2.7.7.48
: RNA-directed RNA polymerase.
3.1.3.84
: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15
: nucleoside-triphosphate phosphatase.
3.6.1.74
: mRNA 5'-phosphatase.
3.6.4.13
: RNA helicase.
External links
PDB
RCSB:3gpq
,
PDBe:3gpq
,
PDBj:3gpq
PDBsum
3gpq
PubMed
19386706
UniProt
Q8JUX6
|POLN_CHIKS Polyprotein P1234
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