Structure of PDB 3geb Chain B Binding Site BS01

Receptor Information
>3geb Chain B (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLAD
THLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHDWMRKLAFRYR
RVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLI
NSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFE
RIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALEL
EYL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3geb Chain B Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3geb Structure of edeya2
Resolution2.4 Å
Binding residue
(original residue number in PDB)		D274 D276
Binding residue
(residue number reindexed from 1)		D7 D9
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0007275 multicellular organism development

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3geb, PDBe:3geb, PDBj:3geb
PDBsum3geb
PubMed
UniProtO00167|EYA2_HUMAN Eyes absent homolog 2 (Gene Name=EYA2)

[Back to BioLiP]