Structure of PDB 3fmr Chain B Binding Site BS01

Receptor Information

>3fmr Chain B (length=356) Species: 6035 (Encephalitozoon cuniculi)

CILLNQAEELPIEFLPKDGVYGKGKLFDSRNMEIENFTESDILQDARRAA
EAHRRARYRVQSIVRPGITLLEIVRSIEDSTRTLLKGERNNGIGFPAGMS
MNSCAAHYTVNPGEQDIVLKEDDVLKIDFGTHSDGRIMDSAFTVAFKENL
EPLLVAAREGTETGIKSLGVDVRVCDIGRDINEVISSYEVEIGGRMWPIR
PISDLHGHSISQFRIHGGISIPAVNNRDTTRIKGDSFYAVETFATTGKGS
IDDRPPCSHFVLNTYKSRKLFNKDLIKVYEFVKDSLGTLPFSPRHLDYYG
LVKGGSLKSVNLLTMMGLLTPYPPLNDIDGCKVAQFEHTVYLSEHGKEVL
TRGDDY

Ligand information

• Ligand ID: FE
• InChI: InChI=1S/Fe/q+3
• InChIKey: VTLYFUHAOXGGBS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Fe+3]
• Formula: Fe
• Name: FE (III) ION
• DrugBank: DB13949
• PDB chain: 3fmr Chain B Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3fmr Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470.
• Resolution: 2.89 Å
• Binding residue (original residue number in PDB): D141 H210 E243 E339
• Binding residue (residue number reindexed from 1): D139 H208 E241 E337
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): D130 D141 H210 H218 E243 E339
• Catalytic site (residue number reindexed from 1): D128 D139 H208 H216 E241 E337
• Enzyme Commision number: 3.4.11.18: methionyl aminopeptidase.

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0004239 initiator methionyl aminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3fmr, PDBe:3fmr, PDBj:3fmr
• PDBsum: 3fmr
• PubMed: 19660503
• UniProt: Q8SR45|MAP2_ENCCU Methionine aminopeptidase 2 (Gene Name=MAP2)