Structure of PDB 3et1 Chain B Binding Site BS01

Receptor Information
>3et1 Chain B (length=270) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLC
MAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFA
NLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLR
KPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIE
KMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIK
KTESDAALHPLLQEIYRDMY
Ligand information
Receptor-Ligand Complex Structure
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PDB3et1 Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent
Resolution2.5 Å
Binding residue
(original residue number in PDB)		T288 K292 L302 N303 Q305 V306 L309 K310 E462
Binding residue
(residue number reindexed from 1)		T90 K94 L104 N105 Q107 V108 L111 K112 E264
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3et1, PDBe:3et1, PDBj:3et1
PDBsum3et1
PubMed19116277
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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