Structure of PDB 3e7a Chain B Binding Site BS01
Receptor Information
>3e7a Chain B (length=293) Species:
9606
(Homo sapiens) [
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LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELE
APLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
LLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCF
NCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
SDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYE
FFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
Ligand information
>3e7a Chain D (length=5) Species:
70799
(Nodularia spumigena) [
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DRtEP
Receptor-Ligand Complex Structure
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PDB
3e7a
Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors
Resolution
1.63 Å
Binding residue
(original residue number in PDB)
R96 S129 Y134 P196 D197 W206 R221 V223 Y272 C273 F276
Binding residue
(residue number reindexed from 1)
R90 S123 Y128 P190 D191 W200 R215 V217 Y266 C267 F270
Enzymatic activity
Catalytic site (original residue number in PDB)
D64 H66 D92 D95 R96 N124 H125 H173 R221 H248
Catalytic site (residue number reindexed from 1)
D58 H60 D86 D89 R90 N118 H119 H167 R215 H242
Enzyme Commision number
3.1.3.16
: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0016787
hydrolase activity
View graph for
Molecular Function
External links
PDB
RCSB:3e7a
,
PDBe:3e7a
,
PDBj:3e7a
PDBsum
3e7a
PubMed
18992256
UniProt
P62136
|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)
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