Structure of PDB 3e1y Chain B Binding Site BS01

Receptor Information
>3e1y Chain B (length=380) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEF
GTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGK
EKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGA
LFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVA
ETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDI
SYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVE
DTLKALEMGAVEILIVYENLDIMRLYLTPEQMPLLEWFANNYKKFGATLE
IVTDKSQEGSQFVKGFGGIGGILRYRVDFQ
Ligand information
Ligand IDATP
InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
FormulaC10 H16 N5 O13 P3
NameADENOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL14249
DrugBankDB00171
ZINCZINC000004261765
PDB chain3e1y Chain A Residue 1526 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3e1y Structural insights into eRF3 and stop codon recognition by eRF1
Resolution3.8 Å
Binding residue
(original residue number in PDB)		T58 A59 I62
Binding residue
(residue number reindexed from 1)		T52 A53 I56
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003747 translation release factor activity
GO:0004045 aminoacyl-tRNA hydrolase activity
GO:0005515 protein binding
GO:0008079 translation termination factor activity
GO:0016149 translation release factor activity, codon specific
GO:0043022 ribosome binding
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0002184 cytoplasmic translational termination
GO:0006412 translation
GO:0006415 translational termination
GO:0006449 regulation of translational termination
GO:0006479 protein methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0018444 translation release factor complex
GO:0022626 cytosolic ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3e1y, PDBe:3e1y, PDBj:3e1y
PDBsum3e1y
PubMed19417105
UniProtP62495|ERF1_HUMAN Eukaryotic peptide chain release factor subunit 1 (Gene Name=ETF1)

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