Structure of PDB 3e0m Chain B Binding Site BS01

Receptor Information

>3e0m Chain B (length=312) Species: 1313 (Streptococcus pneumoniae)

MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLLKETDHA
ETVQVIYDEKEVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDE
ADLPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYC
HIDVTDADKPLIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAY
DQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPLSKELIHYYKDLS
HGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEK
AGYGYLLPYLNK

Ligand information

>3e0m Chain F (length=4)

SHMA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3e0m Structural and Kinetic Analysis of an MsrA-MsrB Fusion Protein from Streptococcus pneumoniae
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): T192 P195 W231 H251 R255 H269 F271 C284
• Binding residue (residue number reindexed from 1): T192 P195 W231 H251 R255 H269 F271 C284

Enzymatic activity

• Catalytic site (original residue number in PDB): C10 Y41 E51 D86 Y91 C150 K159 C229 H266 H269 D273 R282 C284
• Catalytic site (residue number reindexed from 1): C10 Y41 E51 D86 Y91 C150 K159 C229 H266 H269 D273 R282 C284
• Enzyme Commision number: 1.8.4.11: peptide-methionine (S)-S-oxide reductase.
  1.8.4.12: peptide-methionine (R)-S-oxide reductase.

Gene Ontology

Molecular Function

• GO:0008113 peptide-methionine (S)-S-oxide reductase activity
• GO:0016491 oxidoreductase activity
• GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
• GO:0033743 peptide-methionine (R)-S-oxide reductase activity
• GO:0033744 L-methionine:thioredoxin-disulfide S-oxidoreductase activity

Biological Process

• GO:0006979 response to oxidative stress
• GO:0030091 protein repair
• GO:0036211 protein modification process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005886 plasma membrane

External links

• PDB: RCSB:3e0m, PDBe:3e0m, PDBj:3e0m
• PDBsum: 3e0m
• PubMed: 19400786
• UniProt: P0A3Q9|MSAB1_STRPN Peptide methionine sulfoxide reductase MsrA/MsrB 1 (Gene Name=msrAB1)