Structure of PDB 3dyd Chain B Binding Site BS01

Receptor Information
>3dyd Chain B (length=387) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WSVRPSDVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYN
GYAPSIGFLSSREEIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLAN
PGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDE
KTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSD
CKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRD
GLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGAL
AAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPA
TCFEYPNFIRVVITVPEVMMLEACSRIQEFCEQHYHC
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain3dyd Chain B Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3dyd Human Tyrosine Aminotransferase
Resolution2.3 Å
Binding residue
(original residue number in PDB)		C144 S145 F169 N219 D247 I249 Y250 A279 K280 R288
Binding residue
(residue number reindexed from 1)		C87 S88 F112 N162 D190 I192 Y193 A222 K223 R231
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) F169 D247 I249
Catalytic site (residue number reindexed from 1) F112 D190 I192
Enzyme Commision number 2.6.1.5: tyrosine transaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004838 L-tyrosine-2-oxoglutarate transaminase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0009058 biosynthetic process
GO:0009072 aromatic amino acid metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3dyd, PDBe:3dyd, PDBj:3dyd
PDBsum3dyd
PubMed
UniProtP17735|ATTY_HUMAN Tyrosine aminotransferase (Gene Name=TAT)

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