Structure of PDB 3dlh Chain B Binding Site BS01

Receptor Information
>3dlh Chain B (length=666) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVA
RRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDP
KDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGG
AVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRR
TWELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKDP
RKPIPHLTGLLVPVLTLEDLHLALSLPWEERRRRTREIASWIGRRLGLGT
PEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQ
GWPEFLRRALLRAFGGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVL
VLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAK
AGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGGHLLWTLPRIP
QEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREG
IAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHGTPRPLKL
VHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRL
GIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3dlh Structure of the guide-strand-containing argonaute silencing complex.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		A170 Y171 R172 R192 Y197 W202 P218 Y226 H227 R232 I254 P255 H256 L279 M413 W415 R418 K422 Q433 I434 L435 N436 H445 R446 N449 S576 R580 T613 R615 Y642 A644 A648 R651 H657 R661
Binding residue
(residue number reindexed from 1)		A170 Y171 R172 R192 Y197 W202 P218 Y226 H227 R232 I254 P255 H256 L274 M406 W408 R411 K415 Q426 I427 L428 N429 H438 R439 N442 S561 R565 T594 R596 Y623 A625 A629 R632 H638 R642
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3dlh, PDBe:3dlh, PDBj:3dlh
PDBsum3dlh
PubMed18754009
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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