Structure of PDB 3d6m Chain B Binding Site BS01

Receptor Information
>3d6m Chain B (length=88) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AIRKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV
EEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Ligand information
Receptor-Ligand Complex Structure
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PDB3d6m Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever).
Resolution1.8 Å
Binding residue
(original residue number in PDB)		S339 W340 R341 H342 R383
Binding residue
(residue number reindexed from 1)		S23 W24 R25 H26 R67
Enzymatic activity
Catalytic site (original residue number in PDB) E390
Catalytic site (residue number reindexed from 1) E74
Enzyme Commision number 3.4.22.36: caspase-1.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3d6m, PDBe:3d6m, PDBj:3d6m
PDBsum3d6m
PubMed
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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