Structure of PDB 3d3x Chain B Binding Site BS01

Receptor Information
>3d3x Chain B (length=407) Species: 1492 (Clostridium butyricum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKINSFNYNDPVNDRTILYIKPGGCQEFYKSFNIMKNIWIIPERNVIGTT
PQDFHPPTKNGDSSYYDPNYLQSDEEKDRFLKIVTKIFNRINNNLSGGIL
LEELSKANPYLGNDNTPDNQFHIGDASAVEIKFSNGSQDILLPNVIIMGA
EPDLFETNSSNISLRNNYMPSNHGFGSIAIVTFSPEYSFRFNDNSMNEFI
QDPALTLMHELIHSLHGLYGAKGITTKYTITQKQNPLITNIRGTNIEEFL
TFGGTDLNIITSAQSNDIYTNLLADYKKIASKLSKVQVSNPLLNPYKDVF
EAKYGLDKDASGIYSVNINKFNDIFKKLYSFTEFDLATKFQVKCRQTYIG
QYKYFKLSNLLNDSIYNISEGYNINNLKVNFRGQNANLNPRIITPITGRG
LVKKIIR
Ligand information
Receptor-Ligand Complex Structure
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PDB3d3x SNAP-25 substrate peptide (residues 180-183) binds to but bypasses cleavage by catalytically active Clostridium botulinum neurotoxin E.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		E158 T159 N160 T208 H211 E212 N242 T246 R347 Y350 Q353 Y356
Binding residue
(residue number reindexed from 1)		E156 T157 N158 T206 H209 E210 N240 T244 R345 Y348 Q351 Y354
Enzymatic activity
Catalytic site (original residue number in PDB) H211 E212 H215 E250 R347
Catalytic site (residue number reindexed from 1) H209 E210 H213 E248 R345
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3d3x, PDBe:3d3x, PDBj:3d3x
PDBsum3d3x
PubMed18658150
UniProtQ9K395

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