Structure of PDB 3cwd Chain B Binding Site BS01

Receptor Information
>3cwd Chain B (length=260) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMM
GEDKIKQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVT
LLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP
KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQA
LELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLH
PLLQEIYKDL
Ligand information
Receptor-Ligand Complex Structure
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PDB3cwd Molecular recognition of nitrated fatty acids by PPAR gamma.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		E298 K301 L311 Q314 V315 L318 K319 P467 L468 E471
Binding residue
(residue number reindexed from 1)		E82 K85 L95 Q98 V99 L102 K103 P251 L252 E255
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3cwd, PDBe:3cwd, PDBj:3cwd
PDBsum3cwd
PubMed18604218
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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