Structure of PDB 3bu8 Chain B Binding Site BS01

Receptor Information
>3bu8 Chain B (length=207) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLG
KEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTE
FTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLR
NDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKK
ALKSESA
Ligand information
Receptor-Ligand Complex Structure
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PDB3bu8 A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		R80 Q84 L101 R102 Q105 R109 L116 D117 C118 S119 F120 A124 E125
Binding residue
(residue number reindexed from 1)		R38 Q42 L59 R60 Q63 R67 L74 D75 C76 S77 F78 A82 E83
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0042162 telomeric DNA binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000723 telomere maintenance
GO:0031848 protection from non-homologous end joining at telomere
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3bu8, PDBe:3bu8, PDBj:3bu8
PDBsum3bu8
PubMed18202258
UniProtQ15554|TERF2_HUMAN Telomeric repeat-binding factor 2 (Gene Name=TERF2)

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